renal cell carcinoma

カタログ番号	製品名	別名	ターゲット
T26046	Razoxane		Topoisomerase
	Razoxane is used as an antimitotic agent with immunosuppressive properties.		Topoisomerase
T6683	STF-62247	STF 62247	Estrogen/progestogen Receptor , Autophagy
	STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.		Estrogen/progestogen Receptor , Autophagy
T2456	Tivozanib	AV-951,KRN951	VEGFR , PDGFR , Ephrin Receptor
	Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.		VEGFR , PDGFR , Ephrin Receptor
T24818	Sparfosic Acid	NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131	Apoptosis
	Sparfosic Acid (Acide sparfosique) is an aspartate carbamoyltransferase inhibitor with antitumor activity and can be used to study advanced renal cell carcinoma.		Apoptosis
T16777	ROC-325		Apoptosis , Autophagy
	ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity.		Apoptosis , Autophagy
T77810	XPW1		CDK
	XPW1 is a new potent and selective CDK9 inhibitor with antitumour activity that transcriptionally inhibits the DNA repair process in ccRCC cells.XPW1 can be used to study clear cell renal cell carcinoma.		CDK
T16679	Belzutifan	PT2977,MK-6482	HIF
	Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,...		HIF
T1916	Apitolisib	RG 7422,GNE 390,GDC-0980	Apoptosis , PI3K , mTOR
	Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce...		Apoptosis , PI3K , mTOR
T76828	Sonepcizumab	LT 1009	LPL Receptor
	Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell carcinoma (mRCC) to prevent eye scarring after glaucoma fi...		LPL Receptor
T28408	Phosphostim Sodium	IPH1101,Phosphostim,IPH 1101,IPH-1101
	Phosphostim, a gamma9deta2 T lymphocytes agonist, is used potentially for the treatment of renal cell carcinoma, HCV infection.
T31058	CP-461 free base	CEL031,CP461,UNII-824ZMS3BGL,CP-461,OSI-461
	CP-461 (OSI-461) is a pde2a / 5A inhibitor, which may be used in the treatment of renal cell carcinoma, prostate cancer, and Crohn's disease.
T74597	Zifcasiran
	Zifcasiran, a hypoxia-inducible factor (HIF) synthesis reducer, exhibits antitumor activities and is utilized in advanced renal cell carcinoma research [1] [2].
T61442	HIF-1/2α-IN-1
	HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea...
T76803	Elsilimomab
	Elsilimomab (B-E8), an IgG1 monoclonal antibody targeting interleukin-6 (IL-6), exhibits a dissociation constant (K D) of 22 pM and an inhibitory concentration (IC 50) of 1.4 nM. It is applicable in researching multiple ...
T81704	Naptumomab
	Naptumomab, a tumor-targeting superantigen (TTS), is a fusion protein that activates the immune system to recognize and eradicate tumor cells. It shows promise in researching refractory solid tumors, including renal cell...
T36859	C16 Globotriaosylceramide (d18:1/16:0)	C16 Globotriaosylceramide (d18:1/16:0)
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raj...
T63008	PERK-IN-5
	PERK-IN-5 is a highly selective, potent, orally active inhibitor of the protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) that acts on PERK (IC50: 2 nM) and p-eIF2α (IC50: 9 nM). PERK-IN-5 significantly inhi...

Compounds

Razoxane

T26046

Synonym:

Target: Topoisomerase

STF-62247

T6683

Synonym: STF 62247

Target: Estrogen/progestogen Receptor, Autophagy

Tivozanib

T2456

Synonym: AV-951,KRN951

Target: VEGFR, PDGFR, Ephrin Receptor

Sparfosic Acid

T24818

Synonym: NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131

Target: Apoptosis, Autophagy

Synonym: PT2977,MK-6482

Target: HIF

Apitolisib

T1916

Synonym: RG 7422,GNE 390,GDC-0980

Target: Apoptosis, PI3K, mTOR

Synonym: IPH1101,Phosphostim,IPH 1101,IPH-1101

Target:

CP-461 free base

T31058

Synonym: CEL031,CP461,UNII-824ZMS3BGL,CP-461,OSI-461

C16 Globotriaosylceramide (d18:1/16:0)

T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

カタログ番号	製品名	別名	ターゲット
T36439	Gramicidin A		Antibacterial , HIF , Parasite
	Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00724	LDHA Protein, Human, Recombinant (His)	Human	E. coli
	L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,...
TMPK-00172	B7-H4 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A solu...
TMPJ-00457	OGG1 Protein, Human, Recombinant	Human	E. coli
	Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamido...